Cisplatin vs oxaliplatin
WebThe TPF triplet regimen (docetaxel, cisplatin, and 5‐FU) has a trend of further improving treatment efficacy compared with the traditional doublet regimen. 35 , 36 In a phase II study, concurrent chemoradiotherapy with TPF achieved a clinical CR rate of 52.4%, much higher than the previously reported CR rate of 20%. 9 However, the high ... WebThe platinum-based drugs cisplatin, carboplatin and oxaliplatin are regularly prescribed in the treatment of cancer and while they are effective, their use is limited by their severe, dose-limiting side effects (also referred to as adverse effects/events). In total, a cancer patient can experience any combination of around 40 specific side effects.
Cisplatin vs oxaliplatin
Did you know?
WebCisplatin- vs. oxaliplatin-based radiosensitizing chemotherapy for squamous cell carcinoma of the esophagus: a comparison of two preoperative radiochemotherapy regimens Cisplatin- vs. oxaliplatin-based radiosensitizing chemotherapy for squamous cell carcinoma of the esophagus: a comparison of two preoperative radiochemotherapy … WebJan 19, 2024 · The cytotoxic agents that are most commonly associated with infusion reactions are the taxanes, platinum drugs, pegylated liposomal doxorubicin, asparaginase, procarbazine, etoposide, bleomycin, cytarabine, and ixabepilone. While these are often referred to as "hypersensitivity reactions," many do not have a proven immunologic …
WebMar 27, 2024 · (1) Background: Malignant pleural mesothelioma (MPM) is a rare but aggressive tumor arising from the pleural surface. For relapsed MPM, there is no accepted standard of- are for subsequent treatment. Thus, we aimed to compare the efficacy of chemotherapy, targeting drugs, and immune-checkpoint inhibitors (ICIs) as subsequent … WebHKDC1 overexpression conferred chemoresistance to cisplatin, oxaliplatin, and 5‐fluorouracil (5‐Fu) onto GC cells. Furthermore, nuclear factor kappa‐B (NF‐κB) inhibitor PS‐341 could attenuate tumorigenesis, metastasis, and drug resistance ability induced by HKDC1 overexpression in GC cells. Our results highlight a critical role of ...
WebSep 30, 2001 · The choice between cisplatin (cis) and carboplatin (carbo) as the platinum analogue to be used in combination chemotherapy regimens continues to be a point of … WebFeb 28, 2024 · Complex 41 was the only compound selected for the in vitro experiments, although its cytotoxicity was reduced in comparison with oxaliplatin and cisplatin in the HCT116 and A2780 cancer cell lines, with IC 50 = 32.1 μM vs. 0.58 μM and 20.6 μM vs. 1.9 μM, respectively.
WebCisplatin / pharmacology* Combined Modality Therapy Drug Administration Schedule Humans Neoplasms / drug therapy Organoplatinum Compounds / adverse effects …
WebJan 14, 2015 · In the present meta-analysis, we found that oxaliplatin doublets induced similar grades 3 and 4 sensory neuropathies (2.5% vs 7.1%, OR = 0.9, 95% CI = … star images clip art freeWebBackground: Hypersensitivity reactions to platinum salts (PS) (cisplatin [CI], carboplatin [CA], and oxaliplatin [OX]) can be severe and their incidence is increasing due to their … peter brown nz firstWebCarboplatin sIgE is very specific but less sensitive. In contrast, oxaliplatin sIgE had higher sensitivity but lower specificity. Analysis of our data suggests that oxaliplatin exposure was more immunogenic. This could be clinically relevant because patients sensitized to carboplatin may be able to … peter brown new yorkWebCarboplatin sIgE is very specific but less sensitive. In contrast, oxaliplatin sIgE had higher sensitivity but lower specificity. Analysis of our data suggests that oxaliplatin exposure … peter brown plumber harrowWebWe investigated the activity and safety of first-line GEMOX compared with gemcitabine–carboplatin (GCb) in cisplatin-ineligible patients with advanced UCC. … star images from 1970WebJun 27, 2024 · Al-Batran SE, Homann N, Pauligk C, et al. Perioperative chemotherapy with fluorouracil plus leucovorin, oxaliplatin, and docetaxel versus fluorouracil or capecitabine plus cisplatin and epirubicin ... peter brown port hadlockWebSep 22, 2016 · Cisplatin was discontinued for NCI-CTC grade 2 or worse renal toxicity. Oxaliplatin dose modifications were performed as described previously. 9 Toxicity Assessment Toxicities were graded according to NCI-CTC version 2. Peripheral sensitive neuropathy was graded according to an oxaliplatin-specific scale as described … peter brown rhode island