Web1 day ago · However, in Alzheimer’s and other neurodegenerative diseases, P35 is cleaved into a smaller protein called P25, which can also bind to CDK5 but has a longer half-life than P35. ... They designed their peptide with a sequence identical to that of a segment of CDK5 known as the T loop, which is a structure critical to the binding of CDK5 to P25 WebJan 1, 2014 · CDCP1 was immunoprecipitated with mAb 41–2 from primary CAM tumors treated with control IgG (lane 1), mAb 10-D7 (lane 2) or aprotinin (lane 3) as described in …
CDCP1 - CUB domain-containing protein 1 - Sequence
WebJun 15, 2024 · Here, we characterized the precise proteolytic isoforms of CUB domain containing protein 1 (CDCP1), a protein overexpressed and specifically cleaved in RAS … WebMay 28, 2024 · Full length CDCP1 (135 kDa) and its cleaved form ... (Fasmac DNA Sequence Service, Fasmac Co. Ltd.). To analyze the mutations, exon 20 of the EGFR gene was amplified using the forward primer (5 ... hoovercandy.com
Recombinant Human CDCP1 Fc Chimera Protein, CF
WebWe found that in the absence of cofactor Va, the wild-type sequence at the R271 site is cleaved preferentially regardless of its position at the R271 or R320 site, whereas in the presence of cofactor Va, the R320 site is cleaved preferentially regardless of its sequence. Additional single-molecule FRET measurements revealed that the environment ... WebFeb 15, 2024 · These Abs potently targeted cleaved CDCP1-expressing cancer cells as an Ab-drug conjugate, an Ab-radionuclide conjugate, and a bispecific T cell engager. ... The R368/K369 cleavage site was replaced with Px recognition sequence (GS) 5-LEVLFQGP-(GS) 5. (B) SDS-PAGE of CDCP1 constructs. Px treatment cleaves CDCP1(Px)-Fc into … CDCP1/Trask is not important for the development of the mouse. Adult mice lacking CDCP1 do not exhibit gross morphologic, reproductive or behavioral abnormalities compared with wild-type mice, and histologic examination of multiple organ systems has shown no significant pathology and no observed histologic differences. CDCP1 is a ligand for CD6, a receptor molecule expressed on certain T-cells and may play a role in their migration and chemotaxis. As such CD… hoover can1700r