WebSevoflurane (Figure 1) is a nonflammable fluorinated isopropyl ether with a blood/gas coefficient of 0.59. The MAC in 100% oxygen is 1.71 and that in 63% nitrous oxide is 0.66. Sevoflurane reacts with carbon dioxide absorbents to form the haloalkene, compound A, that has been linked to renal injury in some studies, but not in others. WebCompound A is produced when sevoflurane interacts with soda lime or barium hydroxide lime. Reaction with barium hydroxide lime results in a greater production of Compound A than does reaction with soda lime. Its concentration in a circle absorber system increases with increasing sevoflurane concentrations and with decreasing fresh gas flow rates.
Renal toxicity with sevoflurane: a storm in a teacup?
Webwhich sevoflurane was administered to patients under low flow conditions for =2 hours at flow rates of 1 Liter/minute, Compound A levels were measured in an effort to determine the relationship between MAC hours and Compound A levels produced. The relationship between Compound A levels and sevoflurane exposure are shown in Figure 2a. WebSevoflurane, like all currently used volatile anaesthetics, is degraded by carbon dioxide absorbents. The most significant degradant is a haloalkene known trivially as … business bvi publication
Effects of the Water Content of Soda Lime on …
WebCompound M) are limited with additional limits applied for Compound A, Compound M and the largest other single impurity. Sevoflurane does not support the growth of micro-organisms and no microbial test is included in the product specification, which has been justified. II.C.1.2 Scientific data 1.2.1. Nomenclature INN: Sevoflurane WebTable 1 Summary of compound A studies and predicted near steady-state compound A concentrations. a Long-term (10 h) study, b laparoscopic cholecystectomy patients, c … WebSevoflurane C4H3F7O CID 5206 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more. … handpiece turbine service