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Cspg4-creert

WebNational Center for Biotechnology Information WebJul 1, 2024 · CSPG4 plays a central role in the oncogenic pathways required for malignant progression and metastatization. Thanks to these features and to its poor expression in adult healthy tissues, CSPG4 represents an ideal oncoantigen and thus an attractive target for anti-tumor immunotherapy. In this review we explore the potential of CSPG4 immune ...

Chondroitin sulfate proteoglycan 4, a targetable oncoantigen that ...

WebThe CSPG4 and perlecan interaction is involved in cell adhesion and spreading. (A) MM200 cell adhesion on fibronectin coated surface was used as a positive control (i). MM200 cell adhesion on HCAEC perlecan coated surfaces, in the absence of antibody (ii), in the presence of antibodies against α2β1 integrin clone BHA2.1 (iii), against ... WebSep 27, 2016 · Lineage-specific tracing of remyelination by newly-formed oligodendrocytes was accomplished using the Cspg4-CreErt; Mapt-mGFP line. Recombination is induced by a single dose of tamoxifen in NG2 … photo frame living room https://wellpowercounseling.com

Recombination efficiency in 4- and 13-month old Cspg4 …

WebAug 27, 2024 · The NG2-CreERt (The Jackson Laboratory, Catalog # 008538) mouse strain has been described in a previous study (Wang et al., 2024). CreERt expression is under the transcriptional control of the … WebJun 18, 2024 · Chondroitin sulfate proteoglycan 4 (CSPG4) is a potential receptor for C. difficile toxin B (TcdB) during C. difficile infections (CDIs). Here, the cryo-EM structure of … how does forensic psychology benefit society

Structural deciphering of the NG2/CSPG4 proteoglycan …

Category:CSPG4 in cancer: multiple roles - PubMed

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Cspg4-creert

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WebArticle Snippet: Cspg4 CreERT2 mice were used to label cardiac pericytes during embryonic development and is a validated model to label Cspg4 expressing cells and were purchased from The Jackson Laboratory (stock number 008538). Techniques: Derivative Assay, Staining, Immunostaining, Expressing. WebArrows indicating Cspg4/mGFP double positive cells, n = 3 biologically independent mice for each group, two-tailed unpaired t test was used (t(4) = 0.2774, p = 0.7953), scale bar = 100 μm. Points ...

Cspg4-creert

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WebOct 11, 2024 · CSPG4 is a cell surface proteoglycan with oncogenic functions. It recently emerged as a potential target for immunotherapy, including cell therapy based on CSPG4-specific chimeric antigen receptor (CAR)-redirected cytokine-induced killer lymphocytes (CSPG4-CAR.CIKs) in STS. However, expression of CSPG4 is poorly known in STS so far. WebThe People's Clerk is an office-initiated television show designed to highlight the services and initiatives offered in the Clerk of Superior Court. It airs monthly on Fulton …

Web为了模拟老化CNS髓鞘形成减少的现象,探究髓鞘形成减少与空间学习记忆能力下降的关系,研究人员构建了Cspg4-CreErt; Olig2 fl/fl;Mapt-mGFP条件敲基因小鼠。在4月龄小鼠模型中,诱导敲除OPC的转录因子Olig2。 WebMillipore rabbit anti cspg4 Rabbit Anti Cspg4, supplied by Millipore, used in various techniques. Bioz Stars score: 93/100, based on 2 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more

WebCreERT系统实现了基因表达的时间控制,在时间要求精准的科学研究中大放异彩。例如,在记忆的研究中,CreERT系统(或TetTag系统),和即刻早期基因一起,经常作为基因 … WebDec 14, 2024 · The chondroitin sulfate proteoglycan 4 (CSPG4) gene encodes a transmembrane proteoglycan (PG) constituting the largest and most structurally complex macromolecule of the human surf aceome.Its transcript shows an extensive evolutionary conservation and, due to the elaborated intracellular processing of the translated protein, …

WebMar 16, 2024 · The present work addressed the hypothesis that NG2/CSPG4, CD146/MCAM, and VAP1/AOC3 are target genes of myocardin-related transcription factors (MRTFs: myocardin/MYOCD, MRTF-A/MKL1, MRTF-B/MKL2 ...

Chondroitin sulfate proteoglycan 4, also known as melanoma-associated chondroitin sulfate proteoglycan (MCSP) or neuron-glial antigen 2 (NG2), is a chondroitin sulfate proteoglycan that in humans is encoded by the CSPG4 gene. photo frame layout templates for wall layoutWebAug 19, 2014 · Chondroitin sulfate proteoglycan 4 (CSPG4) is a promising target antigen that is overexpressed in multiple cancer histologies including melanoma, triple-negative breast cancer, glioblastoma, mesothelioma and sarcoma. Methods: CSPG4 expression in cancer cell lines was assayed using flow cytometry (FACS) and reverse-transcription … photo frame maker softwareWebJan 24, 2024 · Mutation details: A cre/ERT2 open reading frame and Frt-flanked neomycin cassette replaced exon 1 of the Cspg4 (NG2) locus following homologous recombination in E14.1 ES cells. The neo cassette was deleted by crossing mice to flp expressing mice. No Cspg4 protein is detected in brain lysates. () how does forensics happenWebTumor cells were isolated from the pleural effusions of 12 patients with metastatic breast cancer and incubated sequentially with the chondroitin sulfate proteoglycan 4 (CSPG4)–specific monoclonal antibodies (mAbs) (225.28, 763.74, TP41.2, or TP61.5), phycoerythrin-labeled anti-mouse IgG antibodies, and fluorescein isothiocyanate–labeled … photo frame maker appWebTamoxifen诱导Cre-ERT2小鼠 使用指南. Cre-ERT2在无Tamoxifen诱导的情况下,在细胞质内处于无活性状态;当Tamoxifen诱导后,Tamoxifen的代谢产物4-OHT(雌激素类似 … how does foretell work mtgWebCreERT2-P2A expression cassette was knocked into the Cspg4 gene . Research Application :Cre mouse,Perivascular cell or glial cell. how does forest school link to eyfsWebCSPG4. Chondroitin sulfate proteoglycan 4, also known as melanoma-associated chondroitin sulfate proteoglycan ( MCSP) or neuron-glial antigen 2 ( NG2 ), is a chondroitin sulfate proteoglycan that in humans is encoded by the CSPG4 gene. [5] [6] [7] how does foreshadowing help a story