Epcam biology
WebMay 21, 2024 · Abstract. Epithelial cell adhesion molecule (EpCAM) is a transmembrane glycoprotein primarily known to mediate homotypic cell contacts in epithelia tissues. Because EpCAM expression is limited to normal and malignant epithelia, it has been used as diagnostic marker for the detection of carcinoma cells in mesenchymal organs such … Epithelial cell adhesion molecule (EpCAM), also known as CD326 among other names, is a transmembrane glycoprotein mediating Ca -independent homotypic cell–cell adhesion in epithelia. EpCAM is also involved in cell signaling, migration, proliferation, and differentiation. Additionally, EpCAM has … See more First discovered in 1979, EpCAM was initially described as a dominant surface antigen on human colon carcinoma. Because of its prevalence on many carcinomas, it has been "discovered" many different … See more The exact function of EpCAM is currently being elucidated, but EpCAM appears to play many different roles. Cell adhesion EpCAM was first … See more • FAQs on HNPCC Archived 15 August 2007 at the Wayback Machine from the National Institute of Health • GeneReviews/NCBI/NIH/UW entry on Lynch syndrome See more Although it is identified as a cell adhesion molecule, EpCAM does not structurally resemble any of the four major families of cell adhesion molecules, namely cadherins, integrins, selectins, and members of the immunoglobulin super-family. EpCAM is a See more Target for immunotherapy It has been speculated that since EpCAM in normal epithelia is expressed mostly on the basolateral membrane, it would be much less … See more
Epcam biology
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WebThe epithelial cell adhesion molecule (EpCAM, also designated TACSTD1, CD326) is a type I transmembrane protein of 314 ... Taken together, these studies suggest that the impact of EpCAM expression on cancer biology may be context-dependent (reviewed in van der Gun et al, 2010). Breast cancer is a heterogeneous disease. Recent advances in WebEpCAM-associated functions relate to cell-cell adhesion, proliferation, maintenance of a pluripotent state, regulation of differentiation, migration, and invasion. These functions can be conferred by the full-length protein and/or EpCAM-derived fragments, which are generated upon regulated intramembrane proteolysis.
WebFeb 13, 2024 · Epithelial cell adhesion molecule (EpCAM) is expressed at the basolateral membrane of most normal epithelial cells but is overexpressed in many epithelial cancers. WebAug 7, 2014 · EpCAM is expressed on Clara, ATII, and even potentially on tumor-initiating cells ( 20 – 23 ). Moreover, EpCAM, which can be used to isolate mouse lung epithelial cells ( 20 – 22 ), is overexpressed in lung adenocarcinoma ( 24 ), and is being studied as a target for cancer therapy ( 25 ).
WebNov 11, 2024 · EpCAM is a single-chain membrane-spanning protein consisting of three major domains, termed EpEX, transmembrane domain (TM) and EpICD (Fig. 1 ). EpEX … WebMar 31, 2024 · Each discovery in RNA biology [e.g., primer in CRISPR (7, 8), ... Development of a bifunctional aptamer targeting the transferrin receptor and epithelial cell adhesion molecule (EpCAM) for the …
WebAug 1, 2013 · EpCAM is a cell surface glycoprotein of approximately 40 kDa (detailed below) that is highly expressed in epithelial cancers and at lower levels in normal simple …
WebThe EPCAM gene provides instructions for making a protein known as epithelial cellular adhesion molecule (EpCAM). This protein is found in epithelial cells, which are the cells … journal of molecular recognitionWebJan 11, 2009 · Our finding that EpCAM is a potent signal transducer that uses components of the Wnt pathway, with a proven significance for tumour development and cell renewal … journal of molecular sciences缩写WebNov 15, 2024 · At TJ break sites, EpCAM–claudin-7 complexes on the basolateral membrane become accessible to apical membrane-anchored serine proteinases (MASPs) and the MASPs cleave EpCAM. … how to maintain data protectionWebThe epithelial cell adhesion molecule (EpCAM, CD326) is a glycoprotein of approximately 40 kd that was originally identified as a marker for carcinoma, attributable to its high expression on rapidly proliferating tumors of epithelial origin. ... Here, we provide a comprehensive review of the current knowledge on EpCAM biology in relation to ... journal of molecular psychiatryWebof EpCAM expression with prognosis in different cancers is supported by functional studies of EpCAM biology using in vitro and in vivo cancer models as well. Taken together these studies suggest that the impact of EpCAM expres-sion in human cancers is likely to be context dependent [28]. EpCAM expression based assay has been FDA ap- how to maintain diaryWebStreptavidin-PE was used to place all the lineage marker-positive cells in the PE channel, and EpCAM-APC was used to stain all epithelial cells. At the same time, cells were stained with Annexin V and 7-amino-actinomycin D (7-AAD, PE Annexin V Apoptosis Detection Kit I, BD Biosciences) according to the manufacturer's instructions. journal of molecular recognition abbreviationWebNov 13, 2024 · Epithelial cell adhesion molecule (EpCAM) is the most frequently expressed tumor-associated antigen; it is overexpressed in the majority of human … journal of molecular structure: theochem 影响因子