WebEtomidate is rapidly metabolized in the liver. Minimal hypnotic plasma levels of unchanged drug are equal to or higher than 0.23 mcg/mL; they decrease rapidly up to 30 minutes following injection and thereafter more slowly with a half-life value of about 75 minutes. WebNov 6, 2024 · The half-life period of propofol was about 0.5 to 1.5 hours, and the half-life period of etomidate was about 2 to 5 hours, which was significantly greater than that of propofol. In the PE 1 group, the proportion of etomidate in the admixture was the largest, so the awakening time of patients may be prolonged by the half-life period of etomidate.
AMIDATE (etomidate)injection, USP 2 mg/mL - Pfizer
Webthereafter more slowly with a half-life value of about 75 minutes. Approximately 75% of the administered dose is excreted in the urine during the first day after injection. The chief metabolite is R-(+)-1-(1-phenylethyl)-1H-imidazole-5-carboxylic acid, resulting from hydrolysis of etomidate, and accounts for about 80% of the urinary excretion. WebAug 27, 2024 · Analyzing the reasons, etomidate is an anesthetic widely used in clinics. It has a high binding rate to plasma proteins, can quickly pass through the blood-brain barrier to exert sedative and hypnotic effects, and has the characteristics of short half-life and fast metabolism in the body [12, 13]. healthy base initiative dod
AMIDATE Clinical Pharmacology (etomidate injection, USP)
WebOct 11, 2024 · Although it is well established that etomidate causes adrenal suppression, there is controversy regarding the clinical importance. While evidence from one study … Webthereafter more slowly with a half-life value of about 75 minutes. Approximately 75% of the administered dose is excreted in the urine during the first day after injection. The chief … WebHalf-life: 75 minutes Metabolism: Liver Excretion: Urine Mechanism of Action: GABA agonist See Also References ↑ *Hohl CM, Kelly-Smith CH,Yeung TC, Sweet DD, Doyle … healthy base for smoothies