Web1 Sep 2010 · The exposure variables were the area under the plasma concentration-time curve (AUC) of roflumilast, the AUC of roflumilast N-oxide and tPDE4i. Individual AUC … WebRoflumilast (3-cyclopropylmethoxy-4-difluoromethoxy-n-(3,5-dichloropyrid-4-yl)benzamide) was the first agent of a novel pharmacological class, selective phosphodiesterase 4 …
Roflumilast analogs with improved metabolic stability, plasma …
Web28 Sep 2024 · Arcutis Expands Patent Portfolio with Roflumilast Pharmacokinetics Patent - read this article along with other careers information, tips and advice on BioSpace Arcutis Biotherapeutics, Inc. announced a new patent issued by the United States Patent and Trademark Office covering its invention for improving delivery and extending half-life of … WebIn a Phase I study evaluating the effect of age and gender on the pharmacokinetics of roflumilast and roflumilast N-oxide, a 39% and 33% increase in roflumilast and roflumilast N-oxide AUC were noted in healthy female subjects as compared to healthy male subjects. No dosage adjustment is necessary based on gender. glass network former
Effect of Single and Repeated Doses of Ketoconazole on the ...
Web1 Oct 2009 · To evaluate the effect of co-administration of rifampicin, an inducer of cytochrome P450 (CYP)3A4, on the pharmacokinetics of roflumilast and roflumilast N … Web9 Dec 2024 · The population PK model predicted 42% and 28% higher tPDE4i activity of roflumilast in Blacks and Hispanics, respectively, compared to Caucasians. 5 In a phase I clinical trial conducted on Chinese subjects, the AUC inf of roflumilast and roflumilast N-oxide in Chinese patients was higher than that in Caucasians at the same doses (250 and … Web7 Mar 2013 · For roflumilast N-oxide, AUC and C max decreased by 12% and 20%, respectively. Repeated doses of ketoconazole increased the AUC and C max of roflumilast by 99% and 23%, respectively; for roflumilast N-oxide, AUC was unchanged, and C max decreased by 38%. No clinically relevant adverse events were observed. glass nesting prep bowls