Sting palmitoylation as a therapeutic target
網頁STING palmitoylation as a therapeutic target. Cellular & Molecular Immunology ( IF 8.484 ) Pub Date : 2024-02-22 , DOI: 10.1038/s41423-019-0205-5 網頁STING activation with PAO, as with cGAMP, requires the ER-to-Golgi traffic and palmitoylation of STING. Our results identify a non-nucleotide STING agonist that does not target the cGAMP-binding pocket, and demonstrate that Cys of STING can be a novel target for the development of STING agonist.
Sting palmitoylation as a therapeutic target
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網頁2024年5月6日 · Post-Translational Modifications of STING: A Potential Therapeutic Target. Stimulator of interferon genes (STING) is an endoplasmic-reticulum resident protein, … 網頁2024年3月31日 · We investigated if CKAP4 functions as a diagnostic biomarker and molecular therapeutic target for lung cancer. Methods: CKAP4 secretion with exosomes from lung cancer cells and the effect of CKAP4 palmitoylation on its trafficking to the exosomes were examined. Serum CKAP4 levels were measured in mouse xenograft …
網頁Viro-Immunologist specialist of the porcine model, I am currently working on viral respiratory coinfections. Previous leader of the team “Host/Pathogen Interactions in Pig" in Tours (INRA, France) until my move to VIDO (Canada; Principal Investigator and Adjunct Professor in Veterinary Microbiology). My team there studied host/pathogen interactions in the pig … 網頁Helical filamentous assembly is ubiquitous in biology, but was only recently realized to be broadly employed in the innate immune system of vertebrate…
網頁Strikingly, both types of compounds are reactive nitro-containing electrophiles that target STING palmitoylation, a posttranslational modification necessary for STING signaling. As a consequence, the activation of downstream signaling molecules and the induction of type I interferons were inhibited. 網頁STING inhibition presents a targeted first-in-class therapeutic approach for autoimmune and inflammatory diseases driven by a dysregulated type I IFN response. FRTX-10 in …
網頁2016年6月21日 · Treatment with palmitoylation inhibitor 2-bromopalmitate (2-BP) suppresses palmitoylation of STING and abolishes the type I interferon response. …
global fixed return and growth protector網頁You are here: » STING palmitoylation as a therapeutic target About Aarhus University Organisation Faculties Departments and Schools Research Centres Museums Cafeterias … boeing record retention policy網頁Christian Holm synes godt om dette. Nedlukningerne var en fejl. Sådan lyder det fra Christian Kanstrup Holm, forsker i luftvejsinfektioner og professor ved Institut for … global flash pmi網頁2024年5月6日 · Therefore, PTMs of STING can be important therapeutic target to regulate STING in inflammatory diseases. Targeted PTMs could be potential efficient strategy to … boeing record retention requirements網頁2024年11月29日 · STING Palmitoylation Facilitates VDAC2 Binding and Maintains RCC Growth The critical role of the STING-VDAC2 interaction in promoting tumor growth in … global flash service網頁2024年12月2日 · Another potential target of STING activation is the post-translational palmitoylation of STING that plays a crucial role in its activation. Several small covalent … boeing record retention網頁scientific article published on 22 February 2024 boeing reconciliation action plan